• Joost Hoenderop Ph.D.
• +31 (0)24 36 10580
• j.hoenderop@fysiol.umcn.nl

Joost Hoenderop's background is in molecular-biology and physiology and he obtained his Ph.D. degree in Medical Science at the University of Nijmegen in 2000. As Ph.D., he identified the epithelial calcium channel (TRPV5), which is the gatekeeper of active calcium transport in epithelia present in kidney and intestine. Subsequently, he generated TRPV5 knockout mice as an EMBO-fellow at the Institute of Pharmacology and Toxicology at the University of Lausanne, Switzerland. He is a member of the Young Nephrology Committee from the International Society of Nephrology. In 2010 he became a member of the The Young Academy of The Royal Netherlands Academy of Arts and Sciences. His current work focuses on the regulation of the mineral balance by using several epithelial cell lines and animal models. Hoenderop is a recipient of the prestigious EURYI 2006 grant. In July 2010, he was promoted to full professor in Molecular Renal Physiology.

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Related publications

• The molecular mechanisms of calmodulin action on TRPV5 and the modulation by parathyroid hormone.
  de Groot T, Kovalevskaya NV, Verkaart S, Schilderink N, Felici M, van der Hagen EA, Bindels RJ, Vuister GW, Hoenderop JG.
  Mol Cell Biol 31: 2845-2853, 2011
• Mutations in CYP24A1 and idiopathic infantile hypercalcemia.
  Schlingmann K, Kaufmann M, Weber S, Irwin A, Goos C, John U, Misselwitz J, Klaus G, Kuwertz-BrÃking E, Fehrenbach H, Wingen AM, GÃπran T, Hoenderop JG, Bindels RJ, Prosser DE, Jones, Konrad M.
  N Engl J Med 365: 410-412, 2011
• Klotho prevents renal calcium loss.
  Alexander T, Woudenberg-Vrenken TE, Buurman J, Dijkman H, van der Eerden BC, van Leeuwen PT, Bindels RJ, Hoenderop JG.
  J Am Soc Nephrol 20: 2371-2379, 2009
• A missense mutation in KCNA1 encoding the voltage-gated potassium channel Kv1.1 causes autosomal dominant hypomagnesemia.
  Glaudemans B, van der Wijst J, Scola RH, Lorenzoni PJ, Heister A, van der Kemp AW, Knoers NV, Hoenderop JG, Bindels RJ.
  J Clin Invest 119: 936-942, 2009
• RACK1 inhibits TRPM6 activity via phosphorylation of the fused alfa-kinase domain.
  Cao G, Thebault S, van der Wijst J, van der Kemp A, Lasonder E, Bindels RJ, Hoenderop JG.
  Curr Biol 18: 168-176, 2008
• Calcium absorption across epithelia.
  Hoenderop JG, Nilius B, and Bindels RJ.
  Physiol Rev 85: 373-422, 2005
• The b-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
  Chang Q, Hoefs S, van der Kemp A, Topala C, Bindels RJ, and Hoenderop JG.
  Science 310: 490-493, 2005

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