• René Bindels Ph.D.
• +31 (0)24 36 14211
• r.bindels@fysiol.umcn.nl

René Bindels is as physiologist interested in the regulation of ion transport processes in kidney and small intestine in health and disease. Current projects involve the molecular mechanisms controlling the calcium and magnesium balance in general and the regulation of the new family of epithelial calcium and magnesium channels (TRPV5, TRPV6, TRPM6 and TRPM7) in particular. In addition, the functional consequences of mutations in the human ROMK2, NKCC2, NCC and TRPM6 transporters identified in Bartter and Gitelman syndrome and inherited hypomagnesemia are investigated. The studies include use of established epithelial cell lines, tissue-specific knockout mice models, and electrophysiological and biochemical analysis of channel activity. He is responsible for several physiology courses for medical and health science students. He is an elected member of the Academia Europaea and recipient of the Robert Pitts Lectureship of the International Union of Physiological Sciences, Carl W. Gottschalk Lectureship of the American Physiological Society and Homer Smith award of the American Society of Nephrology. Since 2010 he is the scientific director of the Nijmegen Institute for Molecular Life Sciences (NCMLS).

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Related publications

• Mutations in CYP24A1 and idiopathic infantile hypercalcemia.
  Schlingmann K, Kaufmann M, Weber S, Irwin A, Goos C, John U, Misselwitz J, Klaus G, Kuwertz-BrÃking E, Fehrenbach H, Wingen AM, GÃπran T, Hoenderop JG, Bindels RJ, Prosser DE, Jones, Konrad M.
  N Engl J Med 365: 410-412, 2011
• Gamma-adducin stimulates the thiazide-sensitive NaCl cotransporter.
  Dimke H, San-Cristobal P, de Graaf M, Lenders JW, Deinum J, Hoenderop JG and Bindels RJ.
  J Am Soc Nephrol 22: 508-517, 2011
• 2009 Homer W. Smith Award: Minerals in motion: From new ion transporters to new concepts.
  Bindels RJ.
  J Am Soc Nephrol 21: 1263-1269, 2010
• A missense mutation in KCNA1 encoding the voltage-gated potassium channel Kv1.1 causes autosomal dominant hypomagnesemia.
  Glaudemans B, van der Wijst J, Scola RH, Lorenzoni PJ, Heister A, van der Kemp AW, Knoers NV, Hoenderop JG, Bindels RJ.
  J Clin Invest 119: 936-942, 2009
• Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia.
  Tiel Groenestege W, Thebault S, van der Wijst J, van den Berg D, Janssen R, Tejpar S, van den Heuvel L, van Cutsem E, Hoenderop JG, Knoers NV and Bindels RJ.
  J Clin Invest 117: 2260-2267, 2007
• The b-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
  Chang Q, Hoefs S, van der Kemp A, Topala C, Bindels RJ, and Hoenderop JG.
  Science 310: 490-493, 2005

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