Joris Robben Ph.D.
Post doc
- Joris Robben Ph.D.
- +31 (0)24 36 13684
- j.robben@fysiol.umcn.nl
My research focus are G protein-coupled receptors (GPCRs) that
regulate transport processes in the kidney. Over the last
years I have mainly studied the cell biological effects of
mutations in the vasopressin V2 receptor gene, and how these
mutations cause the inheritable disorder Nephrogenic Diabetes
Insipidus (NDI). Based on this research, we are now testing
small-molecule compounds that will hopefully provide a cure for NDI
in the future. More recently, I started studying the function and
regulation of the succinate receptor GPR91 in the kidney. This is a
relatively new receptor that is involved in the
kidney-mediated onset of hypertension in diabetes mellitus, but
much of its function in renal (patho)physiology remains to be
established. My aim is to set up my own research group that focuses
on the involvement of GPCRs in renal physiology and its associated
inheritable and acquired pathologies. In this, I believe the
research should have a strong translational aspect so there can be
a close link to clinical applications.
Related publications
- Functional variation in the arginine vasopressin 2 receptor as a modifier of human plasma von Willebrand factor levels.
Nossent AY, Robben JH, Deen PMT, Vos HL , Rosendaal FR, Doggen DJM, Hansen JL, Sheikh SP, Bertina RM, Eikenboom JCJ.
J Thromb Haemost 8: 1547-1554, 2010 - Potential of Nonpeptide (Ant)agonists to Rescue Vasopressin V2 Receptor Mutants for the Treatment of X-linked Nephrogenic Diabetes Insipidus.
Los EL, Deen PMT, Robben JH.
J Neuroendocrinol 22: 393-399, 2010 - Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells.
Robben JH, Fenton RA, Vargas SL, Schweer H, Peti-Peterdi J, Deen PMT, Milligan G.
Kidney Int 76: 1258-1267, 2009 - Intracellular activation of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus by nonpeptide agonists.
Robben JH, Kortenoeven MLA, Sze M, Yae C, Milligan M, Oorschot VM, Klumperman J, Knoers NVAM, Deen PMT.
Proc Natl Acad Sci USA 106: 12195-12200, 2009 - Relief of Nocturnal Enuresis by Desmopressin Is Kidney and Vasopressin Type 2 Receptor Independent.
Robben JH, Sze M, Knoers NV, Eggert P, Deen PMT, Müller D.
J Am Soc Nephrol 18: 1534–1539, 2007 - Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.
Robben JH, Sze M, Knoers NV, Deen PM.
Am J Physiol Renal Physiol 292: F253-260, 2007 - Pharmacological Chaperones in Nephrogenic Diabetes Insipidus.
Robben JH, Deen PMT.
Biodrugs 21: 157-166, 2007 - Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.
Robben JH, Sze M, Knoers NVAM, Deen PMT.
Am J Physiol Renal Physiol 292: 253-260, 2007 - Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus.
Robben JH, Knoers NVAM, Deen PMT.
Am J Physiol Renal Physiol 291: 257-270, 2006 - Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus.
Robben JH, Knoers NV, Deen PM.
Am J Physiol Renal Physiol 291: F257-270, 2006 - Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism.
Robben JH, Sze M, Knoers NV, Deen PM.
Mol Biol Cell 17: 379-386, 2006 - Polarisation, key to good localisation.
van Beest M, Robben JH, Savelkoul PJ, Hendriks G, Devonald MA, Konings IB, Lagendijk AK, Karet F, Deen PM.
Biochim Biophys Acta 1758: 1126-1133, 2006 - Rescue of Vasopressin V2 Receptor Mutants by Chemical Chaperones: Specificity and Mechanism.
Robben JH, Sze M, Knoers NVAM, Deen PMT.
Molecular Biology of the Cell 17: 379–386, 2006 - Characterization of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus in a polarized cell model.
Robben JH , Knoers NVAM, Deen PMT.
Am J Physiol Renal Physiol 289: F265–F272, 2005 - Characterization of vasopressin V2 receptor mutants in nephrogenic diabetes insipidus in a polarized cell model.
Robben JH, Knoers NV, Deen PM.
Am J Physiol Renal Physiol 289: F265-272, 2005 - Regulation of the Vasopressin V2 Receptor by Vasopressin in Polarized Renal Collecting Duct Cells.
Robben JH, Knoers NVAM, Deen PMT.
Molecular Biology of the Cell 15: 5693–5699, 2004
